
Modeling
I develop a broad array of computational models to support the design and development of medical devices and models of human disease. Lumped parameter, finite element, and computational fluid dynamics methods allow me to recapitulate and investigate changes in human biomechanics caused by disease.
I am particularly interested in the design of computational models to investigate blood pressures and flows resulting from valvular heart disease, single-ventricle physiology, and heart failure. I then leverage these platforms for the design and optimization of various treatment strategies, such as a pulsatile mechanical circulatory support device for patients with heart failure with preserved ejection fraction. Beyond the cardiovascular applications, I use similar computational tools for the development of a broad spectrum of devices and models, including a low-cost fluidic oscillator for use in an educational simulator of respiratory physiology.
C. Ozturk*, D.H. Pak*, L. Rosalia, D. Goswami, M.E. Robakowski, R. McKay, C.T. Nguyen, J.S. Duncan, E.T. Roche, “AI-powered multimodal modeling of personalized hemodynamics in aortic stenosis”, Adv. Sci, 2024. Link
C. Ozturk*, L. Rosalia*, E.T. Roche, “A multi-domain simulation study of a pulsatile-flow pump device for heart failure with preserved ejection fraction”, Front. Physio, 13 (815787), 2022. Link

T. Dillon*, C. Ozturk*, K. Mendez, L. Rosalia, S.D. Gollob, K. Kempf, E.T. Roche, “Computational Modeling of a Low‐Cost Fluidic Oscillator for Use in an Educational Respiratory Simulator”, Adv. NanoBiomed Res, 2000112, 2021. Link

L. Rosalia*, C. Ozturk*, E.T. Roche, “Lumped-parameter and finite element modeling of heart failure with preserved ejection fraction”, J. Vis. Exp. (168), e62167, 2021. Link

L. Rosalia, C. Ozturk, D. Van Story, M. Horvath, E.T. Roche, “Object-oriented lumped-parameter modeling of the cardiovascular system for physiological and pathophysiological conditions”, Adv. Theory Simul., 2000216, 2021. Link
